886 Experimental Typi - Ioid Fever

The experiments of Grunbaum (1) and of Metchnikoff and Besredka (2) have demonstrated tha t when Bacillus typhosus is introduced into anthropoid apes, certain evidences of human typhoid fever can be reproduced. Positive blood cultures, agglutination reactions, fever, lesions of Peyer 's patches and other features of the disease have been reproduced in this type of animal. The experiments carried out with this organism upon the smaller and more practical laboratory animals have, however, as a whole, proven unsatisfactory. Although a septicemia, peritonitis and death can be readily produced in such smaller animals, the resultant picture bears little if any relationship to the human disease.